Table 1. Class 1 genes with functional group, human and budding yeast orthologs, MC (%) at the indicated time points, average cell length 24 hours after −N, cell number increment 24 hours after −N, and major DNA peaks in VE and 24 hours after −N, measured by FACS.
| Functional group | Strain name | Ortholog | MC (%) |
Cell length |
Cell number |
Major DNA peak |
||||||||
| Human |
Budding yeast |
VE |
24 hours |
1 week |
2 weeks |
3 weeks |
4 weeks |
−N 24 hours (μm) |
Fold change |
VE |
-N 24 hours |
|||
| — | WT | — | — | 104.4 | 97.8 | 87.8 | 103.3 | 90.6 | 90.0 | 4.9 | 3.6 | 2C | 1C | |
| Protein phosphatase– related |
Nem1- Spo7 |
Δnem1 | CTDNEP1 | NEM1 | 96.7 | 80.0 | 5.0 | 3.3 | 2.0 | 2.8 | 5.4 | 3.0 | 2C | 1C |
| ΔSPBC902.03 | CNEP1R1 | SPO7 | 108.3 | 80.0 | 4.8 | 0.0 | 0.0 | 0.0 | 6.2 | 2.4 | 2C | 1C/2C | ||
| CWI | Δrnc1 | HNRNPK | PBP2 | 103.3 | 100.0 | 96.7 | 7.0 | 3.3 | 0.8 | 5.0 | 3.8 | 2C | 1C | |
| PP1 | Δctf1 | CSTF2T | RNA15 | 66.7 | 78.3 | 20.0 | 0.0 | 0.0 | 0.0 | 4.8 | 4.0 | 2C | 1C | |
| PP2A | Δmug134 | ENSA | IGO1 | 110.0 | 106.7 | 50.0 | 8.3 | 5.0 | 5.0 | 10.5 | 2.4 | 2C | 2C | |
| Δpar1 | PPP2R5B | RTS1 | 93.3 | 88.3 | 48.3 | 0.0 | 0.0 | 0.0 | 5.0 | 2.2 | 2C | 2C | ||
| Δypa1 | PPP2R4 | RRD1 | 86.7 | 75.0 | 70.0 | 5.8 | 4.3 | 4.7 | 5.8 | 2.2 | 2C | 2C | ||
| Protein kinase | Δkin1 | MARK | KIN1 | 101.7 | 65.0 | 23.7 | 0.0 | 0.0 | 0.0 | 5.8 | 2.5 | 2C | 2C | |
| RNA/protein process |
Δexo2 | XRN1 | XRN1 | 41.7 | 61.7 | 8.8 | 0.0 | 0.0 | 0.0 | 10.1 | 1.7 | 2C | 2C | |
| Δrpl2002 | RPL18A | RPL20B | 105.0 | 106.7 | 46.7 | 1.2 | 5.8 | 0.0 | 4.4 | 3.5 | 2C | 1C | ||
| Δsbh1 | SEC61B | SBH1 | 61.7 | 63.3 | 5.0 | 1.7 | 0.0 | 1.2 | 4.6 | 4.1 | 2C | 1C | ||
| Vesicle transport |
Δvps3 | TGFBRAP1 | VPS3 | 115.0 | 45.0 | 1.0 | 0.0 | 0.0 | 0.0 | 5.1 | 2.4 | 2C | 1C | |
| Δvps26 | VPS26B | PEP8 | 113.3 | 63.3 | 25.0 | 1.7 | 3.3 | 1.7 | 6.6 | 1.6 | 2C | 2C | ||
| Δvps35 | VPS35 | VPS35 | 78.3 | 30.0 | 5.0 | 0.7 | 0.7 | 0.3 | 7.2 | 1.9 | 2C | 2C | ||
| Transporter | Δvht1 | SLC17 | VHT1 | 70.0 | 90.0 | 10.0 | 0.0 | 0.0 | 0.0 | 6.2 | 1.8 | 1C | 1C | |
| Vacuole | Δaut12 | MON1B | MON1 | 100.0 | 71.7 | 0.0 | 0.0 | 0.0 | 0.0 | 8.2 | 1.4 | 2C | 1C/2C | |
| Δvac7 | — | VAC7 | 108.3 | 71.7 | 0.0 | 0.0 | 0.0 | 0.0 | 8.5 | 2.1 | 2C | 2C | ||
| ΔSPBC83.16c | TTC39B | YKR018C | 103.3 | 90.0 | 7.5 | 0.0 | 0.0 | 0.0 | 4.9 | 3.6 | 2C | 1C | ||
| Metabolism (antioxidant) |
Δsod2 | SOD2 | SOD2 | 76.7 | 48.3 | 3.7 | 0.0 | 0.0 | 0.0 | 5.1 | 2.0 | 2C | 1C | |
| Δspe1 | ODCC1 | SPE1 | 90.0 | 83.3 | 75.0 | 4.2 | 1.0 | 1.8 | 5.0 | 3.1 | 1C/2C | 1C/2C | ||