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. 2018 Aug 15;4(8):eaau6088. doi: 10.1126/sciadv.aau6088

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Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 3 — (A) Ion conduction pathway (cyan) in hTRPV6-CaM, with residues lining the selectivity filter and around the gate shown as sticks. Only two of four hTRPV6 subunits are shown, with the front and back subunits removed for clarity. (B) Pore radius calculated using HOLE (41) for hTRPV6-CaM (inactivated state, green), hTRPV6 (PDB ID: 6BO8; open state, orange), and hTRPV6-R470E (PDB ID: 6BOA; closed state, cyan) (13). Dashed line corresponds to 1.4 Å (radius of a water molecule). (C and D) S6 helices in superposed structures of the inactivated (green), open (orange), and closed (cyan) states described in (A), with the residues contributing to gating shown as sticks. The portion of CaM encompassing K115 is shown in (C).