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. 2018 Aug 15;13(8):e0201553. doi: 10.1371/journal.pone.0201553

Fig 2. Differential expression of actin regulators and Lphn3 related genes in the striatum of High-Active and Control mice.

Fig 2

Average log (base 2) RPKM values (±SE) are shown separately for Control (open bars) and High-Active (shaded bars) lines (n = 10 per bar). A. Gm6180, a pseudogene for Cfl1, was the most significantly upregulated gene in the High-Active line. B. The down regulation of Cfl1 in High-Active relative to Control may be associated with the up regulation of its pseudo gene Gm6180. C. Lphn3 implicated in human ADHD GWAS studies [5,6] displayed decreased expression in High-Active relative to Control mice. D. Flrt3, the gene for the ligand which specifically interacts with Lphn3 to produce transynaptic scaffolding involved in synapse structure was reduced in High-Active relative to Control. *indicates significant difference using standard t test at p<0.05 level.