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. 2018 Jul 20;7:e39775. doi: 10.7554/eLife.39775

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© 2018, Rheinberger et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 2. — (A) Overlay between the cryo-EM structures of apo (green), cAMP-bound (magenta), and cGMP-bound (cyan) SthK in cartoon representation, which shows that the three structures are nearly identical. Only one of the subunits in the tetramer is colored, the other three are in grey. (B) Atomic model of a single SthK subunit in cartoon representation. Red: voltage sensor, green: pore, blue: C-linker, yellow: CNBD. (C) Overlay between apo SthK (green), cAMP HCN1 (blue), apo HCN1 (orange), TAX-4 (red), and LliK (cyan) shows similarities in domain architecture of cyclic nucleotide-modulated ion channels. PDB codes: apo SthK_EM (6CJQ), cAMP SthK_EM (6CJU), cGMP SthK_EM (6CJT), apo HCN1 (5U6O), cAMP HCN1 (5U6P), TAX-4 (5H3O), LliK (5V4S).