Figure 5. Specific lipid-protein interactions in SthK.

(A) View from the extracellular side showing a surface representation of SthK (grey) with the annular lipids (blue) located along the protein periphery. Dashed blue box indicates the region shown in B. (B) Detailed representation of location and possible interactions of the lipids (blue) with amino acid side chains (green) along the extracellular side. Transmembrane helices (grey) are labeled as S1-S6. (C) Side view of the transmembrane domain with all resolved lipids. One subunit was colored green for better visualization. (D) Same view, zoomed-in, of the transmembrane domain, showing the lipid density (in orange mesh) and the modeled lipids (blue). Protein surface representation (grey). Densities shown are at a contour level of 5 σ.