Figure 1.

DCA inhibits agonist-induced platelet aggregation. PRP or washed platelets from human (A) and mouse (B) were stimulated with suboptimal doses of convulxin, collagen, ADP, and thrombin. Results are expressed as the percentage change in light transmission concerning the blank (platelet-poor plasma/buffer without platelets), set at 100%. The upper panel in each bar graph denotes the representative aggregation curves (blue, control; black, 10 mM DCA; red, 25 mM DCA). For mouse studies, PRP or washed platelets were pooled from 3 to 4 mice (n = 5 individual experiments per group). For human studies, PRP or washed platelets are from the individual donors (n = 5 per group). Values are mean ± SEM. *P < .05 vs control (vehicle).