Table 3.
Iron studies of Tfrc+/L645R and Tfrc+/R654H mice
| Mean ± SD | |||
|---|---|---|---|
| WT (n = 9) | Tfrc+/L645R (n = 6) | Tfrc+/R654H (n = 5) | |
| Serum Tf, g/L | 3.80 ± 1.2 | 4.24 ± 0.68 | 3.99 ± 0.87 |
| Serum ferritin, μg/L | 1021 ± 130.6 | 905 ± 228.8 | 908 ± 125.2 |
| RBC ferritin, μg/L | 60.43 ± 9.54 | 17.22 ± 1.21* | 28.70 ± 8.65* |
| Serum iron, μmol/L | 47.21 ± 2.23 | 38.09 ± 9.29* | 47.90 ± 27.6 |
| TIBC, μmol/L | 115.84 ± 11.7 | 106.68 ± 6.82 | 95.92 ± 15.7* |
| Tf saturation, % | 48.95 ± 2.59 | 35.85 ± 2.16* | 55.75 ± 2.33* |
| Liver iron, nmol/kg | 1.89 ± 0.25 | 1.64 ± 0.34 | 1.62 ± 0.46 |
Serum and tissue iron parameters obtained from 10-week-old WT, RBC6 (Tfrc+/L645R), and RBC21 (Tfrc+/R654H) mice. Two-tailed Student t test was used to compare values with WT.
TIBC, total iron binding capacity.
*
P < .05.