Table 5.

Iron studies of Tfrc^+/L645R and Tfrc^+/R654H mice after iron (dextran) treatment

	Mean ± SD
	WT	Tfrc+/L645R	Tfrc+/R654H
Serum Tf, g/L	9.33 ± 2.44	8.22 ± 0.55	8.23 ± 3.90
Serum ferritin, μg/L	3427 ± 445	3220 ± 315	3939 ± 567
RBC ferritin, μg/L	148.2 ± 3.68	27.80 ± 7.9*	38.64 ± 5.63*
Serum iron, μmol/L	83.90 ± 9.91	77.03 ± 17.4	78.80 ± 2.59
TIBC, μmol/L	89.06 ± 12.1	79.04 ± 21.4	86.73 ± 15.6
Tf saturation, %	71.28 ± 15.1	64.2 ± 19.8	82.37 ± 19.8
Liver iron, nmol/kg	2.81 ± 0.73	3.72 ± 1.37	2.69 ± 0.54
MCV, fL	48.0 v 2.5	39.5 ± 1.5*	35.7 ± 1.6*
MCH, pg	14.7 ± 0.42	12.4 ± 0.51*	11.2 ± 0.25*

Blood and tissue iron parameters obtained from 10-week-old WT, RBC6 (+/L645R), and RBC21 (+/R654H) mice, 3 weeks after a single intraperitoneal injection of iron dextran. Two-tailed Student t test was used to compare values with the WT.

^*P < .05.