Figure 6: Localized chemo- or radio-therapy hydrogels improves survival by inhibiting tumor growth.

Nude mice were implanted subcutaneously with D54 cells stably expressing luciferase mixed with matrigel. After 10 days, mice were imaged with bioluminescence imaging and then stratified into three groups of ten mice each. Mice were treated with localized TMZ-hydrogels (10mg) or ¹³¹I-hydrogels (4Gy) or controlled empty hydrogel. A) Representative BLI pictures of three mice implanted with control (left), chemotherapy (middle) or radiotherapy hydrogels (right) at day 27 after implantation. B) The effect of hydrogel implantation (empty-control, TMZ, or Rx-4Gy) on tumor progression monitored for 27 days using bioluminescent imagining (BLI) and shown as the average of the luminescent signal of ten mice. C) Kaplan-Meyer survival curves following various treatments of mice bearing subcutaneous brain tumors.