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. Author manuscript; available in PMC: 2018 Aug 16.
Published in final edited form as: ACS Chem Neurosci. 2018 Apr 6;9(8):1939–1950. doi: 10.1021/acschemneuro.7b00475

Figure 4.

Figure 4.

Role of the avpr1a microsatellite in regulating expression levels of V1aR. (A) In the 5′ flanking region of avpr1a, the nonmonogamous meadow vole has a nearly nonexistent microsatellite, while prairie voles have a polymorphic microsatellite-containing element. Reprinted/adapted with permission from Springer Nature: Springer. Animal Models of Behavior Genetics by J.C. Gewirtz, Y.-K. Kim (eds.), copyright 2016. (B) There exists a diversity of avpr1a microsatellite alleles within a population of semiwild prairie voles ranging from 711 bp to 760 bp. (C) In vitro luciferase reporter assays indicate that the length of the microsatellite correlates with expression of V1aR. (D) Clockwise from top left, audioradiograms of transgenic mice with the meadow vole microsatellite, the short prairie vole microsatellite, or the long prairie vole microsatellite, with quantification of V1aR density in different brain region. Brain regions: ventral pallidum (VP), lateral septum (LS), paraventricular nucleus of the thalamus (PVthal), central amygdala (CeA), and dentate gyrus (DG). Reprinted/adapted by permission from Springer Nature: Springer. Animal Models of Behavior Genetics by J.C. Gewirtz, Y.-K. Kim (eds.), copyright 2016. (A) and (D) reprinted from ref 75 with permission from AAAS, 2005. (B) and (C) reprinted from ref 76 with permission from AAAS, 2005.