Skip to main content
. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Nat Prod Rep. 2018 Aug 15;35(8):792–837. doi: 10.1039/c7np00067g

Fig. 22.

Fig. 22

Pentalenolactone and neopentalenolactone biosynthesis. (A) The biosynthetic pathways of pentalenolactone 203 and neopentalenolactone 206. PenH/PntH/PtlH catalyzes the hydroxylation of 1-deoxypentalenic acid to 11-β-hydroxy-1-deoxypentalenic acid 198.275 (B) Crystal structure of PtlH•Fe•αKG showing a proximal-type αKG (brown sticks) coordination to the iron centre (yellow sphere). (C) Notably, the structure of PtlH with the substrate analogue ent-1-deoxypentalenic acid (green sticks) reveals a conformation change of an active site Y142 relative to that in (B), where there is no substrate.