Table 2.
Multiple linear regression (β; 95% Confidence Interval) for the association of cardiorespiratory fitness (CRF) with adiposity and cardiometabolic risk factors, HCHS/SOL Youth (n=1380)*
| CRF | Quartiles of CRF | ||||
|---|---|---|---|---|---|
|
| |||||
| Each 10mL/kg/min | p-value | Quartile 2 | Quartile 3 | Quartile 4 | |
| Adiposity | |||||
|
| |||||
| BMI, z-score | −0.48 (−0.60, −0.36) | <0.0001 | −0.38 (−0.60, −0.16) | −0.66 (−0.88, −0.44) | −0.97 (−1.21, −0.73) |
| WC, z-score | −0.48 (−0.57, −0.39) | <0.0001 | −0.45 (−0.65, −0.25) | −0.71 (−0.91, −0.52) | −0.92 (−1.11, −0.73) |
| BF, % | −5.35 (−6.34, −4.35) | <0.0001 | −5.1 (−7.1, −3.0) | −8.4 (−10.3, −6.4) | −10.8 (−12.8, −8.8) |
|
| |||||
| Blood Pressure | |||||
|
| |||||
| SBP, percentile | |||||
| Model 1 | −3.78 (−5.96, −1.60) | 0.0007 | −0.1 (−4.6, 4.3) | −2.6 (−7.6, 2.4) | −9.5 (−13.9, −5.2) |
| Model 2† | −3.36 (−5.84, −0.88) | 0.0081 | 0.3 (−4.2, 4.8) | −2.0 (−7.3, 3.2) | −8.8 (−13.7, −3.8) |
| DBP, percentile | |||||
| Model 1 | −5.93 (−7.97, −3.88) | <0.0001 | −3.6 (−7.8, 0.6) | −8.6 (−12.7, −4.4) | −12.0 (−16.1, −8.0) |
| Model 2† | −4.45 (−6.57, −2.32) | <0.0001 | −2.2 (−6.4, 2.0) | −6.3 (−10.5, −2.1) | −9.1 (−13.3, −4.8) |
|
| |||||
| Glycemic markers | |||||
|
| |||||
| FPG, mg/dL | |||||
| Model 1 | −0.60 (−1.22, 0.02) | 0.0596 | −0.7 (−1.9, 0.4) | −1.1 (−2.3, 0.1) | −1.3 (−2.7, 0.0) |
| Model 2† | −0.37 (−0.99, 0.26) | 0.2516 | −0.5 (−1.6, 0.6) | −0.8 (−1.9, 0.4) | −0.9 (−2.2, 0.4) |
| HbA1c, % | |||||
| Model 1 | −0.04 (−0.06, −0.01) | 0.0094 | −0.08 (−0.13, −0.02) | −0.08 (−0.14, −0.02) | −0.06 (−0.12, 0.01) |
| Model 2† | −0.01 (−0.04, 0.02) | 0.3878 | −0.05 (−0.11, 0.00) | −0.05 (−0.10, 0.01) | −0.01 (−0.07, 0.05) |
| log(HOMA-IR) | |||||
| Model 1 | −0.27 (−0.33, −0.21) | <0.0001 | −0.30 (−0.44, −0.17) | −0.36 (−0.49, −0.22) | −0.54 (−0.67, −0.42) |
| Model 2† | −0.10 (−0.16, −0.05) | 0.0003 | −0.14 (−0.26, −0.03) | −0.10 (−0.21, 0.01) | −0.22 (−0.34, −0.10) |
|
| |||||
| Lipids | |||||
|
| |||||
| Cholesterol, mg/dL | |||||
| Model 1 | −4.94 (−7.43, −2.46) | 0.0001 | −3.1 (−8.2, 2.0) | −5.4 (−11.2, 0.5) | −10.1 (−15.2, −5.0) |
| Model 2† | −4.03 (−6.62, −1.43) | 0.0025 | −2.2 (−7.4, 3.0) | −3.9 (−9.9, 2.2) | −8.2 (−13.4, −2.9) |
| HDL, mg/dL | |||||
| Model 1 | 1.74 (0.79, 2.70) | 0.0004 | 2.4 (0.4, 4.3) | 2.4 (0.4, 4.4) | 3.8 (1.8, 5.8) |
| Model 2† | −0.37 (−1.29, 0.54) | 0.4217 | 0.4 (−1.3, 2.2) | −0.7 (−2.6, 1.2) | −0.2 (−2.1, 1.8) |
| LDL, mg/dL | |||||
| Model 1 | −3.71 (−5.85, −1.56) | 0.0008 | −2.9 (−7.4, 1.6) | −4.2 (−9.2, 0.9) | −8.0 (−12.5, −3.5) |
| Model 2† | −2.19 (−4.39, 0.01) | 0.0511 | −1.5 (−5.9, 2.9) | −1.9 (−7.1, 3.2) | −5.1 (−9.6, −0.5) |
| log(TG, mg/dL) | |||||
| Model 1 | −0.18 (−0.23, −0.13) | <0.0001 | −0.14 (−0.25, −0.03) | −0.22 (−0.33, −0.10) | −0.36 (−0.46, −0.25) |
| Model 2† | −0.09 (−0.15, −0.04) | 0.0007 | −0.06 (−0.16, 0.04) | −0.09 (−0.20, 0.02) | −0.19 (−0.30, −0.09) |
Lowest quartile of CRF is the reference category for quartile analysis; values are betas (95% confidence intervals) derived from survey linear regression models adjusted for age, sex, field center, Hispanic/Latino background, place of birth, annual household income, and parent education level, MVPA, and sedentary behavior.
Model 2 is further adjusted for waist circumference z-score.
BF, body fat; BMI, body mass index; CRF, cardiorespiratory fitness; DBP, diastolic blood pressure; FPG, fasting plasma glucose; HDL, high density lipoprotein; HOMA-IR, homeostasis model assessment – insulin resistance; LDL, low density lipoprotein; SBP, systolic blood pressure; TC, total cholesterol; TG, triglycerides; WC, waist circumference.