Table 3.
Multiple linear regression (β; 95% Confidence interval) for the association of cardiorespiratory fitness (CRF) with adiponectin, inflammatory markers, and e-selectin. HCHS/SOL Youth (n=1380)*
| CRF | Quartiles of CRF | ||||
|---|---|---|---|---|---|
|
| |||||
| Each 10mL/kg/min | p-value | Quartile 2 | Quartile 3 | Quartile 4 | |
| log(CRP, mg/dL) | |||||
| Model 1 | −0.44 (−0.55, −0.33) | <0.0001 | −0.46 (−0.69, −0.24) | −0.70 (−0.94, −0.46) | −0.88 (−1.13, −0.63) |
| Model 2† | −0.14 (−0.24, −0.04) | 0.0088 | −0.18 (−0.36, 0.00) | −0.25 (−0.46, −0.04) | −0.31 (−0.54, −0.07) |
|
| |||||
| log(PAI-1, ng/mL) | |||||
| Model 1 | −0.29 (−0.37, −0.20) | <0.0001 | −0.28 (−0.43, −0.13) | −0.36 (−0.52, −0.20) | −0.59 (−0.78, −0.40) |
| Model 2† | −0.09 (−0.17, −0.01) | 0.0300 | −0.10 (−0.24, 0.04) | −0.07 (−0.22, 0.08) | −0.22 (−0.39, −0.04) |
|
| |||||
| Adiponectin, ug/mL | |||||
| Model 1 | 0.59 (0.22, 0.96) | 0.0019 | 0.72 (−0.08, 1.52) | 0.82 (0.02, 1.61) | 1.31 (0.54, 2.08) |
| Model 2† | −0.08 (−0.47, 0.31) | 0.6783 | 0.11 (−0.61, 0.84) | −0.16 (−0.98, 0.65) | 0.06 (−0.73, 0.85) |
|
| |||||
| log(e-selectin, ng/mL) | |||||
| Model 1 | −0.08 (−0.12, −0.04) | <0.0001 | −0.07 (−0.14, 0.01) | −0.08 (−0.15, −0.01) | −0.18 (−0.26, −0.10) |
| Model 2† | −0.03 (−0.07, 0.01) | 0.1206 | −0.02 (−0.09, 0.05) | 0.00 (−0.07, 0.07) | −0.08 (−0.16, 0.00) |
*
Lowest quartile of CRF is the reference category for quartile analysis; values are betas (95% confidence intervals) derived from survey linear regression models adjusted for age, sex, field center, national background, place of birth, annual household income, and parent education level, physical activity, and sedentary behavior.
†
Model 2 is additionally adjusted for waist circumference z-score.
CRF, cardiorespiratory fitness; CRP, C-reactive protein; PAI-1, plasminogen activator inhibitor-1.