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Change in Montgomery-Asberg Depression Rating Scale (MADRS) total score for the healthy control (HC) and major depressive disorder (MDD) groups for both ketamine (red) and placebo (blue) infusions over the course of the study. The group mean is shown as a circle, and the error bars are the standard error. The linear timescale indicates the timing of the imaging scans (green circles), infusions (red triangle), and rating scale administrations (blue rectangles).
