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Antibiotic structures and spectrum of activity. Broad-spectrum antibiotics (effective against Gram-positive and Gram-negative pathogens), and Gram-positive-only antibiotics. Although information on the precise mode of entry into Gram-negative bacteria is not definitive, data suggests that antibiotics can enter Gram-negative bacteria through porins, the self-promoted uptake, or through a combination of both. *Colistin is Gram-negative only.
