Table 5.
Baseline patient characteristics by core laboratory sensitization status for samples obtained at study enrollment (a) and at the time of transplantation (b).
| Characteristics, n (%) | a: Enrollment Sample
|
b: Transplanted Sample
|
||||||
|---|---|---|---|---|---|---|---|---|
| Non-Sensitized (n=116) | Sensitized (n = 156) | p-Value | Total (n = 272) | Non-Sensitized (n=108) | Sensitized (n = 129) | p-Value | Total (n = 237) | |
| Listing Characteristics | ||||||||
| Age at Listing in years, median (IQR) | 4 (1–13) | 7 (1–14) | 0.0849 | 6 (1–14) | 5 (1–13) | 8 (1–14) | 0.0675 | 6 (1–14) |
| Weight at Listing in kg, median (IQR) | 15.6 (6.9–40.2) | 20.5 (9.8–50.4) | 0.0287 | 18.2 (8.5–47.8) | 15.5 (6.8–40.1) | 21.5 (10.2–52.9) | 0.0057 | 18.4 (8.5–49.0) |
| Diagnosis | 0.1854 | 0.0047 | ||||||
| Cardiomyopathy | 64 (55.2) | 71 (45.5) | 135 (49.6) | 70 (64.8) | 58 (45.0) | 128 (54.0) | ||
| Congenital Heart Disease | 51 (44.0) | 80 (51.3) | 131 (48.2) | 37 (34.3) | 68 (52.7) | 105 (44.3) | ||
| Other | 1 (0.9) | 5 (3.2) | 6 (2.2) | 1 (0.9) | 3 (2.3) | 4 (1.7) | ||
| Race | 0.0087 | 0.1230 | ||||||
| White | 71 (61.2) | 86 (55.1) | 157 (57.7) | 62 (57.4) | 70 (54.3) | 132 (55.7) | ||
| Black or African American | 18 (15.5) | 39 (25.0) | 57 (21.0) | 20 (18.5) | 34 (26.4) | 54 (22.8) | ||
| Non-White/Non-Black | 13 (11.2) | 5 (3.2) | 18 (6.6) | 11 (10.2) | 6 (4.7) | 17 (7.2) | ||
| Unknown or Not Reported | 14 (12.1) | 26 (16.7) | 40 (14.7) | 15 (13.9) | 19 (14.7) | 34 (14.3) | ||
| Ethnicity | 0.0886 | 0.5093 | ||||||
| Hispanic or Latino | 11 (9.5) | 24 (15.4) | 35 (12.9) | 12 (11.1) | 18 (14.0) | 30 (12.7) | ||
| Not Hispanic or Latino | 87 (75.0) | 98 (62.8) | 185 (68.0) | 74 (68.5) | 85 (65.9) | 159 (67.1) | ||
| Unknown or Not Reported | 18 (15.5) | 34 (21.8) | 52 (19.1) | 22 (20.4) | 26 (20.2) | 48 (20.3) | ||
| Male | 54 (46.6) | 96 (61.5) | 0.0140 | 150 (55.1) | 44 (40.7) | 82 (63.6) | 0.0005 | 126 (53.2) |
| Blood Type | 0.7305 | 0.8506 | ||||||
| A | 33 (28.4) | 47 (30.1) | 80 (29.4) | 37 (34.3) | 38 (29.5) | 75 (31.6) | ||
| AB | 5 (4.3) | 4 (2.6) | 9 (3.3) | 3 (2.8) | 5 (3.9) | 8 (3.4) | ||
| B | 21 (18.1) | 23 (14.7) | 44 (16.2) | 19 (17.6) | 22 (17.1) | 41 (17.3) | ||
| O | 57 (49.1) | 82 (52.6) | 139 (51.1) | 49 (45.4) | 64 (49.6) | 113 (47.7) | ||
| UNOS Status at Listing | 0.1700 | 0.1161 | ||||||
| 1A | 79 (68.1) | 99 (63.5) | 178 (65.4) | 79 (73.1) | 83 (64.3) | 162 (68.4) | ||
| 1B | 21 (18.1) | 21 (13.5) | 42 (15.4) | 18 (16.7) | 19 (14.7) | 37 (15.6) | ||
| 2 | 16 (13.8) | 35 (22.4) | 51 (18.8) | 11 (10.2) | 26 (20.2) | 37 (15.6) | ||
| 7 | 0 | 1 (0.6) | 1 (0.4) | 0 | 1 (0.8) | 1 (0.4) | ||
| Prior Sensitizing Event | 86 (74.1) | 130 (83.3) | 0.0636 | 216 (79.4) | 77 (71.3) | 105 (81.4) | 0.0666 | 182 (76.8) |
| Surgery | 53 (45.7) | 103 (66.0) | 0.0008 | 156 (57.4) | 45 (41.7) | 84 (65.1) | 0.0003 | 129 (54.4) |
| Blood Transfusion | 53 (45.7) | 100 (64.1) | 0.0025 | 153 (56.3) | 48 (44.4) | 78 (60.5) | 0.0138 | 126 (53.2) |
| VAD | 27 (23.3) | 36 (23.1) | 0.9693 | 63 (23.2) | 24 (22.2) | 31 (24.0) | 0.7425 | 55 (23.2) |
| ECMO | 10 (8.6) | 24 (15.4) | 0.0953 | 34 (12.5) | 8 (7.4) | 20 (15.5) | 0.0545 | 28 (11.8) |
| Any MCS | 34 (29.3) | 48 (30.8) | 0.7954 | 82 (30.1) | 30 (27.8) | 41 (31.8) | 0.5026 | 71 (30.0) |
| Aortic or Pulmonary Allograft | 11 (9.5) | 34 (21.8) | 0.0069 | 45 (16.5) | 7 (6.5) | 30 (23.3) | 0.0004 | 37 (15.6) |
| Prior Transplant | 1 (0.9) | 15 (9.6) | 0.0024 | 16 (5.9) | 2 (1.9) | 12 (9.3) | 0.0154 | 14 (5.9) |
| Pregnancy | 1 (0.9) | 0 | 0.4265 | 1 (0.4) | 1 (0.9) | 0 | 0.4557 | 1 (0.4) |
| Hospitalized at Listing | 88 (75.9) | 101 (64.7) | 0.0489 | 189 (69.5) | 84 (77.8) | 84 (65.1) | 0.0326 | 168 (70.9) |
| ICU at Listing | 59 (50.9) | 64 (41.0) | 0.1070 | 123 (45.2) | 55 (50.9) | 54 (41.9) | 0.1631 | 109 (46.0) |
| Ventilator at Listing | 20 (17.2) | 20 (12.8) | 0.3086 | 40 (14.7) | 19 (17.6) | 17 (13.2) | 0.3457 | 36 (15.2) |
| ECMO at Listing | 2 (1.7) | 4 (2.6) | 1.0000 | 6 (2.2) | 1 (0.9) | 3 (2.3) | 0.6278 | 4 (1.7) |
| VAD at Listing | 13 (11.2) | 17 (10.9) | 0.9358 | 30 (11.0) | 11 (10.2) | 17 (13.2) | 0.4771 | 28 (11.8) |
| MCS at Listing | 15 (12.9) | 20 (12.8) | 0.9785 | 35 (12.9) | 12 (11.1) | 20 (15.5) | 0.3244 | 32 (13.5) |
| Transplant Characteristics1 | ||||||||
| Age at Transplant in years, median (IQR) | 5 (0–13) | 8 (1–14) | 0.0761 | 6 (1–14) | ||||
| Weight at Transplant in kg, median (IQR) | 15.6 (8.0–40.1) | 25.2 (10.7–51.7) | 0.0129 | 20.6 (9.2–50.0) | ||||
| UNOS Status at Transplant | 0.5744 | |||||||
| 1A | 92 (85.2) | 112 (86.8) | 204 (86.1) | |||||
| 1B | 12 (11.1) | 10 (7.8) | 22 (9.3) | |||||
| 2 | 4 (3.7) | 7 (5.4) | 11 (4.6) | |||||
| Hospitalized at Transplant | 84 (77.8) | 89 (69.0) | 0.1292 | 173 (73.0) | ||||
| ICU at Transplant | 48 (44.4) | 53 (41.1) | 0.6025 | 101 (42.6) | ||||
| Ventilator at Transplant | 17 (15.7) | 16 (12.4) | 0.4598 | 33 (13.9) | ||||
| ECMO at Transplant | 6 (5.6) | 3 (2.3) | 0.3069 | 9 (3.8) | ||||
| VAD at Transplant | 18 (16.7) | 26 (20.2) | 0.4915 | 44 (18.6) | ||||
| MCS at Transplant | 24 (22.2) | 29 (22.5) | 0.9621 | 53 (22.4) | ||||
IQR, interquartile range; UNOS, United Network for Organ Sharing; VAD, ventricular assist device; ECMO, extracorporeal membrane oxygenation; MCS, mechanical circulatory support; ICU, intensive care unit
1
Data only available for transplanted recipients.