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. 2018 Jul 5;5(8):935–951. doi: 10.1002/acn3.592

Figure 12.

Figure 12

Alterations in voluntary running activity induced by 5F5 and 2G6 mAbs. (A) Voluntary running activity was measured in mice before and after receiving 5F5, 2G6, or both mAbs. Prior to mAb administration, the mice received a dose of LPS to open the blood brain barrier. Baseline levels were recorded for 4 days prior to LPS/mAb administration, and compared to the 4 day steady state period following recovery from LPS toxicity. The differences in the average number of daily wheel revolutions are shown. One‐way ANOVA *P = 0.026, **P = 0.033, ***P = 0.0005. (B) Voluntary running activity was measured in mice before and after receiving MK‐801 (100 μg/kg or 50 μg/kg). Baseline levels were recorded for 4 days prior to MK‐801 injection, and compared to the 4 days following the injection. The differences in the average numbers of daily wheel revolutions are shown. One‐way ANOVA *P = 0.0001, **P = 0.0001. Error bars indicate S.E.M.