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. 2018 Aug 15;8:12163. doi: 10.1038/s41598-018-29683-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GZ17 formulations modulate levels of several phospho-proteins in HNSCC. (A) HNSCC cells (OSC19; 2 × 10⁵ cells) were treated with vehicle control or ED₅₀ concentrations of GZ17-6.02, -05.00 or –S for 48 h. Representative dot-blot image from phospho-kinase array. (B) Densitometric analyses of dot-blot image signals from GZ17 treated lysates normalized to those from vehicle control and presented as fold change in protein levels. The graph represents cumulative data from two independent experiments. Error bars represent ± SEM. (C) HNSCC cells (OSC19; 2 × 10⁵ cells) were treated with ED₅₀ concentrations of GZ17-6.02, -05.00, –S or vehicle control for 72 h. Immunoblot was performed for phospho-ERK1/2 and total ERK1/2 as loading control. Image is representative of three independent experimental repeats. (D) Densitometric analyses of signals from immunoblots normalized to loading control and presented as fold change in protein levels relative to vehicle control treated cells. Error bars represent ± SEM.