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. 2018 Aug 15;8:12236. doi: 10.1038/s41598-018-30362-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of ER stress-responsive factors in response to Tm in the CRELD2-deficient Neuro2a cells. (A) The parental or cloned CRELD2-deficient (CRELD2 KO) Neuro2a cells were treated with Tm (1 μg/ml) or vehicle for 12 h and expression level of each mRNA was determined as described in the Materials and methods section. (B) The parental, hygromycin selected (KD) and a cloned (KO) Neuro2a cells were treated with Tm for the indicated time and the expression level of each protein was determined as described in the Materials and methods section. Relative amount of genes and proteins was calculated as described in the Materials and methods section. The values obtained from untreated parental cells (A) or the parental Neuro2a cells after 12 h of treatment with Tm (B) were considered as “100%”. Each value represents the mean ± SEM from 5 independent cultures.