Table 1.
Transcripts altered in COPD quadriceps (vastus lateralis) relative to healthy controls.
| TC | P-value | Adj. P-value | FC | Symbol | Description | Module (MM) |
|---|---|---|---|---|---|---|
| 8123246 | 1.06E-11 | 1.71E-07 | 3.35 | SLC22A3 | Cation transport | Yellow (0.78) |
| 8099551 | 8.74E-09 | 1.02E-05 | 2.13 | FAM184B | — | Yellow (0.74) |
| 8119088 | 9.46E-09 | 1.04E-05 | 2.53 | CDKN1A | Cell cycle arrest; satellite cell regeneration; DNA damage response | Turquoise (−0.75) |
| 8105302 | 1.33E-08 | 1.28E-05 | 2.00 | FST | Growth factor; Wnt signalling; satellite cell regeneration | Turquoise (−0.60) |
| 7958724 | 1.86E-07 | 5.05E-05 | −2.65 | LINC01405 | — | Turquoise (0.67) |
| 8157173 | 4.27E-07 | 7.79E-05 | 2.21 | MUSK | Neuromuscular synapse formation/transmission | Turquoise (−0.75) |
| 7943218 | 2.96E-06 | 2.97E-04 | 2.08 | PANX1 | Gap junctions; potentiation of skeletal muscle contraction; ATP release; mechanosensitive | Blue (0.82) |
| 7934979 | 3.31E-06 | 3.26E-04 | 2.25 | ANKRD1 | Transcription factor; monocyte stress response; apoptosis; stretch-sensitive | Blue (0.73) |
| 7958253 | 1.09E-05 | 7.16E-04 | −2.66 | C12orf75 | Wnt signalling; energy metabolism | Turquoise (0.62) |
| 8012726 | 1.57E-05 | 9.11E-04 | 2.21 | MYH1 | Myosin - heavy chain (type IIx fibres) | Yellow (0.66) |
| 7971077 | 2.17E-05 | 1.14E-03 | 3.53 | POSTN | Stress response; inflammation; wound healing | Blue (0.78) |
| 8057506 | 3.57E-05 | 1.60E-03 | 2.62 | FRZB | Wnt signalling; growth, proliferation & differentiation | Brown (0.54) |
| 8163637 | 4.29E-05 | 1.80E-03 | 3.03 | TNC | Stress response; inflammation; wound healing | Blue (0.79) |
| 7987315 | 1.30E-04 | 3.75E-03 | 2.50 | ACTC1 | Actin | Blue (0.77) |
| 8068363 | 3.58E-04 | 7.92E-03 | −2.03 | LINC00310 | – | Blue (−0.62) |
| 8012787 | 6.88E-04 | 1.28E-02 | 2.00 | MYH3 | Myosin - embryonic | Blue (0.74) |
| 7923534 | 7.73E-04 | 1.38E-02 | 2.73 | MYBPH | Myosin binding protein; actin-myosin interaction | Blue (0.81) |
| 8095744 | 3.86E-03 | 4.26E-02 | 2.01 | AREG | Growth factor; satellite cell regeneration | Green (0.55) |
The Table 1 lists transcripts differentially expressed by COPD disease status in the quadriceps (vastus lateralis) significant at a 5% FDR and accompanied by an absolute fold change ≥2. Abbreviations: Transcript Cluster (TC), Fold Change (FC), Module Membership (MM).