Table 2.
Differentially expressed genes previously reported in the EBI GWAS catalogue under the search term ‘chronic obstructive pulmonary disease’.
| Reported gene | TC | Adj. P-Value | Module | GWAS trait | GWAS reference |
|---|---|---|---|---|---|
| PLCE1 | 7929388 | 1.24E-03 | blue | Lifetime average cigarettes per day in chronic obstructive pulmonary disease | 43 |
| LINC00310 | 8068363 | 7.92E-03 | blue | Percentage gas trapping | 44 |
| SCFD2 | 8100347 | 1.86E-02 | blue | Lifetime average cigarettes per day in chronic obstructive pulmonary disease | 43 |
| C5orf56 | 8107934 | 2.85E-02 | blue | Lung function (FEV1/FVC) | 19 |
| KCNQ5 | 8120654 | 2.35E-04 | brown | Lung function (FEV1/FVC) | 19 |
| RRM2B | 8152133 | 2.07E-02 | brown | Chronic obstructive pulmonary disease | 16 |
| PAPD4 | 8106534 | 4.34E-02 | brown | Post bronchodilator FEV1/FVC ratio in COPD | 20 |
| ABCC4 | 7972297 | 4.66E-02 | brown | Airway responsiveness in chronic obstructive pulmonary disease | 45 |
| LPAR1 | 8163257 | 6.91E-05 | green | Post bronchodilator FEV1 in COPD | 20 |
| ABI3BP | 8089145 | 4.51E-03 | green | Post bronchodilator FEV1 in COPD | 20 |
| DLC1 | 8149413 | 8.86E-03 | grey | Emphysema imaging phenotypes; Percentage gas trapping | 44 |
| RARB | 8078286 | 4.91E-02 | grey | Airway responsiveness in chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease | 16, 45 |
| PDZD2 | 8104693 | 3.41E-03 | red | Chronic obstructive pulmonary disease | 46 |
| FAM13A | 8101728 | 6.40E-05 | turquoise | Chronic obstructive pulmonary disease; Chronic bronchitis and chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease (moderate to severe); Chronic obstructive pulmonary disease (severe); Lung function (FEV1/FVC) | 13– 19 |
| CACNA2D3 | 8080578 | 2.38E-04 | turquoise | Lung function (FEV1/FVC) | 19 |
| MN1 | 8075126 | 1.23E-03 | turquoise | Lung function (FEV1) | 19 |
| CDH23 | 7928218 | 1.55E-03 | turquoise | Age at smoking initiation in chronic obstructive pulmonary disease | 43 |
| NNT | 8105153 | 2.54E-03 | turquoise | Post bronchodilator FEV1/FVC ratio in COPD | 20 |
| THSD4 | 7984588 | 3.67E-03 | turquoise | Chronic obstructive pulmonary disease; Lung function (FEV1/FVC) | 16, 19 |
| KCNS3 | 8040458 | 5.69E-03 | turquoise | Lung function (FEV1); Lung function (FEV1/FVC) | 19 |
| MICAL3 | 8074274 | 1.20E-02 | turquoise | Lung function (FEV1) | 19 |
| MLYCD | 7997525 | 1.36E-02 | turquoise | Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) | 47 |
| PLXNA4 | 8142997 | 1.63E-02 | turquoise | Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) | 47 |
| AZIN1 | 8152222 | 1.66E-02 | turquoise | Airway imaging phenotypes | 44 |
| VWA8 | 7971246 | 2.41E-02 | turquoise | Local histogram emphysema pattern | 48 |
| ARMC2 | 8121370 | 2.91E-02 | turquoise | Chronic obstructive pulmonary disease; Lung function (FEV1/FVC) | 16, 19 |
| MICAL3 | 8074286 | 3.31E-02 | turquoise | Lung function (FEV1) | 19 |
| CDH13 | 7997504 | 3.46E-02 | turquoise | Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) | 47 |
| AGFG1 | 8048847 | 3.88E-02 | turquoise | Airway hyperresponsiveness | 49 |
| ABLIM2 | 8099279 | 2.70E-02 | yellow | Post bronchodilator FEV1 in COPD | 20 |
| PPM1L | 8083749 | 4.65E-02 | yellow | Post bronchodilator FEV1/FVC ratio in COPD | 20 |
The table lists transcripts differentially expressed by COPD disease status in the quadriceps (vastus lateralis) at a 5% FDR and catalogued under the annotation ‘chronic obstructive pulmonary disease’ in the NHGRI-EBI GWAS database12 as accessed on 12/06/2018.
Abbreviations: Transcript Cluster (TC), Fold Change (FC), Genome-Wide Association Study (GWAS), Module Membership (MM).