Table 3.
COPD-related peripheral muscle co-expression modules.
| Module | N | Peak MM | Top GO BP (adj. P value) | Top GO CC (adj. P value) | Top DGA (adj. P value) |
|---|---|---|---|---|---|
| Blue | 264 | TC 8051443 (0.88), STRN | NS | NS | umls:C0349782 Ischemic cardiomyopathy (3.29E-04) |
| Brown | 231 | TC 8044161 (0.82),– | GO:0048193 Golgi vesicle transport; GO:0051603 Proteolysis involved in cellular protein catabolic process (1.76E-02) |
GO:0044446 Intracellular organelle part; GO:0044422 Organelle part (4.80E-04) |
NS |
| Green | 93 | TC 8089145 (0.87), ABI3BP | GO:0030199 Collagen fibril organization (7.89E-04) | GO:0005615 Extracellular space (7.60E-08) | umls:C0034069 Pulmonary Fibrosis (1.82E-05) |
| Red | 39 | TC 7919349 (0.86),– | GO:0006614 SRP-dependent co-translational protein targeting to membrane; GO:0006613 Co-translational protein targeting to membrane; GO:0045047 Protein targeting to ER; GO:0072599 Establishment of protein localization to endoplasmic reticulum (1.97E-04) |
GO:0022626 Cytosolic ribosome (1.83E-03) | NS |
| Turquoise | 899 | TC 7991374 (0.91), IDH2 | GO:0055114 Oxidation-reduction process (3.04E-43) | GO:0044429 Mitochondrial part (5.35E-53) | umls:C0023264 Leigh Disease (1.01E-08) |
| Yellow | 105 | TC 8046646 (0.84), OSBPL6 | NS | GO:0043292 Contractile fiber (1.92E-10) | NS |
| Unassigned | 195 | ||||
| Sum | 1826 |
The table summarises detected gene co-expression modules. The number of module members is shown as N, the transcript showing the highest module membership is reported with module membership (MM) shown in brackets. Functional, cellular and clinical context is provided through top enriched gene and disease ontology terms, with the false discovery rate controlled at 5%. Tied terms are reported. Abbreviations: Module Membership (MM), Gene Ontology (GO), Biological Process (BP), Cellular Component (CC), Transcript Cluster (TC), Not Significant (NS), Disease-Gene Association (DGA), Unified Medical Language System (UMLS), Disease Ontology ID (DOID).