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. 2018 Aug 15;3:20. doi: 10.1038/s41525-018-0062-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — AUC of target ranking using series of balance factors. Representative targets were used to depict different scenarios resulting from balanced factors analysis. Each color line represents a target. Target names as well as their AUC rankings are shown in the figure. Neutral set of balance factor is b1 = 0.5 and b2 = 0.5, e.g., active and inactive assay both contributes half in the final ranking. Rankings of this balance factor are also displayed in the middle of each line. Overall, this neutral balance factor ranking correlates very well with the AUC ranking as we expected (Kendall’s rank correlation τ = 0.865)