Table 1.
Summary of 18 selected modulators
| Target | Specific modulator | Type of modulation | Suppression of gluconeogenesis (%) | Suppression on top of insulin (%) |
|---|---|---|---|---|
| AURKB | AZD1152HQPA | Inhibitor | 4 | 1 |
| CACNA1E | SNX482 | Blocker | 25 | 26 |
| CXCR2 | MK7123a | Antagonist | NA | NA |
| DRD3 | SB277011-A | Antagonist | 84 | 51 |
| ESR1 | ICI182,780 | Antagonist | 19 | 7 |
| GRM1 | A841720 | Antagonist | 2 | 3 |
| HTR1A | WAY100635 | Antagonist | 29 | 33 |
| HTR6 | SB-742457 | Antagonist | 15 | 4 |
| HTR7 | SB269970 | Antagonist | 12 | 7 |
| LXR | GW3965 | Agonist | 72 | 38 |
| OPRD1 | SB205607 | Agonist | 20 | 4 |
| P2RX7 | A740003 | Antagonist | −6 | 1 |
| RARA | BMS753 | Agonist | −28 | −19 |
| RPS6KB2 | SL0101 | Inhibitor | 1 | 3 |
| RXRA | CD3254 | Agonist | 11 | 3 |
| SCD | Ab142089 | Inhibitor | 31 | 26 |
| TRPM8 | AMTBb | Blocker | NA | NA |
| TRPV1 | A 784168b | Antagonist | NA | NA |
The effects on gluconeogenesis in combination with insulin (ainterference with detection method, bcytotoxicity). The values in the table represent three replicated experiments