Fig. 7.

Revised working model of the main host oncogenic gene dependencies in PEL cell lines. a Genes involved in NF-κB and Jak/Stat signaling are dispensable in most PEL cell lines and may serve fitness functions. b Addiction to constitutively active mTOR signaling was not captured in this study, due to confounding housekeeping function of mTOR. c Critical PEL-specific oncogene dependencies (PSODs) on IRF4, MDM2, CCND2, CFLAR, and MCL1 (in blue), most of which are druggable using agents shown in red