Figure 5.

Upstream Regulator Analysis of Neurospheroids and 2D Differentiation

(A) Venn diagram of differentially expressed genes associated with extracellular space and plasma membrane in neurospheroids and 2D differentiation (Srikanth et al., 2015).

(B) Top five upstream regulators predicted in IPA to be responsible for the differential gene expression of exclusively modulated genes (extracellular space and plasma membrane genes only) in 3D (665 genes) and 2D (755 genes). The activation scores and p values are graphically represented by different colors and sphere sizes, respectively.

(C) Regulatory networks derived for 3D and 2D data based on IPA predictions for the top five upstream regulators.

See also Figure S5.