Fig. 1. rPEGylation of arginine-rich AMPs. (a) Synthesis of arginine-reactive polymers ((i): tosyl chloride, triethylamine; (ii): o-substituted p-hydroxyacetophenone, K2CO3). (b) Sequence and 3D structure (inset from ref. 21 with permission) of model AMP (3) and controls with one (4) or no arginine residues (5). Structure of three forms (6–8) of the conjugates obtained. Letters represent single letter codes for amino acids (underlined are d-amino acids).
