Fig. 5. Analysis of HCT116 cell viability% screened with 166 RAS complexes reveal that structural isomerism do not affect efficacy of RAS complexes. (a) Summary of cell viabilities, classified into four sub bands. Selected comparison of cell viability% between the groups treated with RAS complexes (b) having different arene ligands. Mean ± S.E.M. (n = 51, ****p < 0.0001; paired one-way ANOVA test with Tukey post-hoc test); (c) having different picolinaldehyde (PA) ligands. Mean ± S.E.M. (n = 24, ns – not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; paired one-way ANOVA test with Tukey post-hoc test); and (d) having aniline derivative (AD) ligands with R′ moieties in the meta or para position. Mean ± S.E.M. (n = 65, ns – not significant; paired two-tailed t-test).