Table 2. NHS mediated Cα-heteroarylation of tetrahydrofuran with diverse heteroarenes ^a .

^aSee the general procedure for the experimental details unless otherwise noted. The isolated yield was reported for each reaction.

^bPerformed with 5 equiv. of THF.

^cThe reaction time was extended to 72 h.

^d 3p, mono-substituted product (C-2) : bis-substituted product (C-2 and C-6) = 10 : 1 (r.r.); 3q, C-6 product only (r.r.); the regiomeric ratio (r.r.) was determined using ¹H NMR spectroscopy.

^e20 equiv. of THF were employed.