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. 2018 Jun 15;26(8):1965–1972. doi: 10.1016/j.ymthe.2018.05.013

Figure 2.

Figure 2

In Vivo Transduction Efficiency in Immunohistochemically Identified Cell Types

(A and C) Single confocal images of striatal sections from WT mice receiving rAAV9-shGluN3A at 1 month of age (green) and stained by immunohistochemistry for specific cell type markers upon sacrifice, 2 weeks after delivery (red) (A: NeuN, all neurons; DARPP-32, MSNs; ChAT, cholinergic neurons; C: GFAP, astrocytes; Olig2, oligodendrocytes). Solid arrows, examples of colocalization; dashed arrows, no colocalization. Scale bars, 10 μm. (B) Quantification of striatal cells positive for a given marker transduced by rAAV9-shGluN3A. Data are mean ± SEM (n = 4 animals per group, five striatal fields at different antero-posterior levels were analyzed per mouse).