Figure 7.

EMAPII mAb Subcutaneous Injections Reduce Levels of Released EMAPII, Weight Loss, and Indices of Lung Injury in IAV-Infected Mice

(A) Mice received 750 pfu/mouse IAV or equal volume of saline (cntr). Half of IAV-infected mice were treated with EMAPII mAb (2.5 mg/kg) on days 4, 6, and 8 post-infection. Mice were analyzed for (B) EMAPII levels in BALF, (C) IAV-induced weight loss, (D) conscious blood oxygenation, (E) lung edema and protein in BALF (day 9), and (F) BALF caspase 3/7 activity (day 9). n = 5 for all groups; data are presented as mean ± SEM. *p < 0.05 by ANOVA with Tukey post-hoc (B and D–F) or repeated-measurements ANOVA (C).