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. 2018 Summer;17(3):995–1007.

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Human lymphocytes’ lysosomal membrane integrity after treatment with PFOS. Destabilization of lysosomal membrane in human lymphocytes after treatment with PFOS. Measurement of acridine orange (a tertiary amine that accumulates in lysosome) redistribution to cytosol was used as an indicator of damage to lysosomal membrane. One-hundred fifty and tree-hundred µM PFOS significantly (P < 0.05) induced lysosomal membrane leakage after 6 h incubation in comparison with control. BHT and chloroquine attenuated PFOS-induced lysosomal membrane destabilization.^*P < 0.05, ^**P < 0.01 and ^***P < 0.001.