Fig. 6.

The effect of hypoxia on migration and invasion in HMM cells. (a) Hypoxia significantly increased migration in HMM cells. (b) Hypoxia significantly enhanced invasion in H513 cells. (c) Phase contrast images (400× magnification) of HMM cells cultured for 48 h under normoxia or hypoxia are presented. (d) Hypoxia induced a loss of E-cadherin expression and a gain of vimentin expression in HMM cells. E-cadherin expression was not detected in MS1 cells. *P value < 0.05, as calculated by Student’s t-test