FIG 2 .

Topographic imaging reveals major structural differences between corneocytes with high and low NFM levels. Height images (z-range = 2 µm) (A, D, G, and J) and corresponding deflection images (B, E, H, and K) recorded in PBS for corneocytes from patients with high NMF levels (high NMF₁ and high NMF₂) or low NMF levels (low NMF₁ and low NMF₂). (C, F, I, and L) High-resolution height images recorded in the square areas shown in panels A, D, G, and J, together with vertical cross sections taken along the dashed lines.