Figure 5.

A Schematic Illustration Summarizing the Effects of Tamoxifen Treatment on MGCs and Photoreceptors in Pde6b^H620Q/STOPPde6g^Cre/+ Mouse Models

(A) A line graph comparing the photoreceptor layer thickness between treated (solid blue line) and untreated (dotted blue line) Pde6b^H620Q/STOPPde6g^Cre/+ mice over time. Approximately 2 weeks after treatment, the photoreceptor layer thickness in Pde6b^H620Q/STOPPde6g^Cre/+ mice plateaus and remains constant over time. (B) A line graph comparing MGC density between treated (solid orange line) and untreated (dotted orange line) Pde6b^H620Q/STOPPde6g^Cre/+ mice over time. MGC density and inflammation returned to normal WT levels by 6 weeks after tamoxifen treatment.