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Genetic Rescue Reversed the Migration of Microglia
Microglial CX3CR1 expression was studied in Pde6bH620Q/STOP;Pde6gCre/+ retinal cross-sections at 2, 6, and 14 weeks after treatment. No CX3CR1 signal was detected in the IS/OS layer and ONL. The thickness of the ONL and photoreceptor nuclear density remained at the same level from 2 to 14 weeks for all three different time points of treatment (green, GFP; blue, DAPI; yellow bar, ONL; magenta bar, INL; scale bar, 100 μm).
