Table 2.

Comparison of incidence of FN and SN.

	Direct comparison		Indirect comparison
Outcome	LIP vs. PEG RR (95% CI)	FIL vs. PEG RR (95% CI)	LIP vs. FIL (via PEG)  RR (95% CI)
% FN	0.34 (0.05, 2.14)	1.54 (1.03, 2.29)	0.22 (0.03, 1.51)
% SN cycle 1	0.80 (0.63, 1.03)	1.01 (0.93, 1.10)	0.79 (0.61, 1.03)
% SN cycles 2–4	0.53 (0.35, 0.79)	1.17 (0.86, 1.59)	0.45 (0.27, 0.75)

CI: confidence interval; FIL: filgrastim; FN: febrile neutropenia; LIP: lipegfilgrastim; PEG: pegfilgrastim; RR: risk ratio; SN: severe neutropenia.