Table 3.
Comparison of time to ANC recovery, duration of SN, and incidence of bone pain.a
| Direct comparison |
Indirect comparison |
||
|---|---|---|---|
| Outcome | LIP vs. PEG Mean difference (95% CI) | FIL vs. PEG Mean difference (95% CI) | LIP vs. FIL (via PEG) Mean difference (95% CI) |
| Time to ANC recovery, days | −1.75 (−2.61, −0.90) | 0.28 (−0.10, 0.60) | −1.88 (−2.82, −0.95) |
| Duration of SN, days | −0.17 (−0.39, 0.04) | 0.00 (−0.28, 0.28) | −0.17 (−0.53, 0.19) |
| % Bone pain | 1.12 (0.66, 1.90) | 1.05 (0.80, 1.36) | 1.07 (0.59, 1.93) |
ANC: absolute neutrophil count; CI: confidence interval; FIL: filgrastim; LIP: lipegfilgrastim; PEG: pegfilgrastim; RR: risk ratio; SN: severe neutropenia.
a
RR reported for bone pain.