Table 2. . Management of ipilimumab immune-related adverse events.
| Immune-related adverse event | Management strategies | |
|---|---|---|
| Grade | ||
| Mild | Severe | |
| Dermatologic | Oral antihistaminics | Systemic steroids + oral taper |
| – Rash | Topical steroids | |
| – Vitiligo | Urea/hydrating cream | |
| – Pruritis | ||
| Gastrointestinal | Antidiarrheals | Systemic steroids + oral taper |
| – Diarrhea | Hydration | Infliximab |
| – Colitis | Electrolyte substitution | |
| Endocrine | – | Systemic steroids + oral taper + hormone replacement |
| – Hypophysitis | ||
| Hepatic | ||
| – Hepatitis | – | Systemic steroids + oral taper |
| Immunosuppressive therapy | ||