Table 5. . Management of BRAF^V600 inhibitor toxicities.

Toxicity	Management
Skin toxicities
Rash	Diphehydramine 25–50 mg po q6h prn
	Hydrorxyzine 25–50 mg po q6h prn
	Urea 10–22% loc appl prn
	Hydrating cream loc appl prn
	Hydrocortisone 1% or betamethasone 0.1% loc appl prn
Photosensitivity	Protective clothing, avoid sunlight
	Sun block of at least 30 SPF
Secondary malignancies
Squamous cell skin cancer	Close follow-up by dermatologist
Keratoacanthoma
Gastrointestinal
Diarrhea	Loperamide 2 mg po prn max 16 mg/day
	Diphenoxylate/atropine 1–2 tabs po q6–8h prn
Nausea, vomiting	Metoclopramide 10 mg po q6h prn
	Prochlorperazin 10 mg po/pr q6h prn
Musculoskeletal
Arthralgia	Acetaminophen 325–650 mg po q4–6h prn
	Ibuprofen 200–400 mg po q6h prn†

^†Or equivalent.

po: Per os; Prn: If needed; q6h: Every 6 h; SPF: Sun protection factor.