Table 4. . Outcomes of ipilimumab-treated patients who received pembrolizumab.
Pt# | Best response to ipilimumab | Time (days) between PD and pembrolizumab | Best response to pembrolizumab | Total cycles received | PFS (months)† | OS (months)† |
---|---|---|---|---|---|---|
1 | PD | 29 | PR | 41, ceased due to PD | 36.9 | 44.7 |
2 | PD | 187‡ | CR | 33, ceased due to CR/AE | NR, 47.4+ | NR, 47.4+ |
9 | PD | 15 | PD | 4, ceased due to PD | 2.3 | 5.3 |
10 | PR | 34 | PD | 2, ceased due to PD | 1.8 | 3.9 |
12 | Not assessed | 21 (planned switch) | PD | 3 | 3.2 | 9.6 |
13 | PD | 39 | SD | 20+, ongoing | NR, 13.5+ | NR, 13.5+ |
†From time of initiating pembrolizumab.
‡This patient received chemotherapy with four cycles of carboplatin/paclitaxel and had a sustained PR of 5 months.
AE: Adverse event; CR: Complete response; NR: Not reached; OS: Overall survival; PD: Progressive disease; PFS: Progression-free survival; PR: Partial response; Pt#: Patient number; SD: Stable disease.