Table 1. . Summary of key neurosurgery studies.

Study	No. of BMs	No. of patients (% melanoma)	Treatment (n)	Local control (%)	Median functionally independence survival	Median overall survival	Ref.
Patchell et al.	Solitary	48 (6)	Surgery + WBRT (25) WBRT	20† 52†	38 weeks† 8 weeks†	40 weeks† 15 weeks†	[18]‡
Vecht et al.	Solitary	63 (10)	Surgery + WBRT (32) WBRT	NR	7.5 months§ 3.5 months§	10 months† 6 months†	[19]‡
Mintz et al.	Solitary	84 (5)	Surgery + WBRT (41) WBRT	NR	No difference	6.28 months 5.62 months	[20]‡
Bindal et al.	Multiple	56 (45)	Resection of some BMs (30) Resection of all BMs (26) Matched control (solitary BM) (26)	NR 4¶ 8¶	NR	6 months† 14 months† 14 months	[21]#
Konstadoulakis et al.	Mixed	136 (100)	Surgery (32) WBRT or chemotherapy or both (75) No therapy (29)	NR	NR	6.67%†,†† 3.45%†,††	[22]

^†Statistically significant difference.

^‡Randomized.

^§p = 0.06.

^¶Percentage local relapse.

^#Retrospective.

^††At 1 year.

BM: Brain metastases; NR: Not reported; WBRT: Whole brain radiotherapy.