Table 2. . Summary of key whole brain radiotherapy studies.

Study	No. of patients (% melanoma)	Treatment (no.)	Local control (%)	Median overall survival (months)	Ref.
Brown et al.	41 (56)	SRS alone 18 Gy (15) SRS + WBRT 30–50Gy/10–25 fx	SRS alone: 85†SRS + WBRT: 100†‡	14.2	[24]
Hauswald et al.	87 (100)	WBRT 30 Gy/10 fx (56) 40 Gy/20 fx (31)	NR	All: 3.5 30 Gy: 3.1 40 Gy: 5.6‡	[28]
Rades et al.	51 (100)	WBRT 30 Gy/10 fx (33) 40 Gy/20 fx (11) 45 Gy/15 fx (7)	30 Gy: 23† 40–45 Gy: 50†,‡	30 Gy: 27%† 40–45 Gy: 50%†‡	[29]
Ellerhorst et al.	87 (100)	WBRT 15–50 Gy/5–25 fx	NR	4.75	[30]
Dyer et al.	147 (100)	SRS + Up-front WBRT (39) + Salvage WBRT (33)	NR	7.3	[31]

^†At 6 months;

^‡statistically significant difference.

fx: Fractions; NR: Not reported; SRS: Stereotactic radiosurgery; WBRT: Whole brain radiotherapy.