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. 2018 May 28;26(8):1940–1952. doi: 10.1016/j.ymthe.2018.05.006

Figure 3.

Figure 3

Fe-S Cluster Protein Deficit and Cellular Iron Metabolism Dysregulation in Some Neurons of Pvalb cKO Mice

(A) Representative SDH histoenzymatic activity staining in lumbar DRGs at 8.5 weeks of age WT and Pvalb cKO mice. Scale bars, 100 μm. (B) Scoring SDH staining intensity in lumbar DRG neurons at 5.5 weeks of age; n = 8,732 neurons counted from three WT animals and n = 11,019 neurons counted from four Pvalb cKO animals. *p < 0.05. (C) Representative SDH histoenzymatic activity staining in cerebellum at 13.5 and 18.5 weeks of age WT and Pvalb cKO mice with magnifications on Purkinje cells. Scale bars, 100 μm. (D) Representative images of TfR1 immunofluorescence (green) in cerebellum of WT and Pvalb cKO animals at 13.5 weeks of age. Scale bars, 100 μm. (E) Representative images of TfR1 (red) and GFAP (green) co-immunofluorescence in cerebellum of WT and Pvalb cKO animals at 18.5 weeks of age. Scale bars, 100 μm.