Table 3.

Top 25 up-regulated genes in NSIP vs. IPF (SAM analysis)

NCBI Gene Symbol	NCBI Gene name	d	Fold change vs. NSIP group	q value
LRP2	LDL receptor related protein 2	4.49	2.12	< 0.0001
IFI44L	interferon-induced protein 44-like	3.99	2.67	< 0.0001
SLC39A8	solute carrier family 39 (zinc transporter), member 8	3.97	2.67	0.0237
SCN1A	sodium channel, voltage gated, type I alpha subunit	3.96	1.97	0.0237
LNX2	ligand of numb-protein X 2	3.86	1.52	0.0237
WARS	tryptophanyl-tRNA synthetase	3.82	1.63	0.0237
SLC6A14	solute carrier family 6 (amino acid transporter), member 14	3.76	2.54	0.0237
FZD5	frizzled class receptor 5	3.76	1.61	0.0237
PCDH9	protocadherin 9	3.71	1.53	0.0237
F11	coagulation factor XI//4q35	3.68	2.50	0.0237
RSAD2	radical S-adenosyl methionine domain containing 2	3.63	2.26	0.0237
NECAB1	N-terminal EF-hand calcium binding protein 1	3.60	2.48	0.0237
MFSD2A	major facilitator superfamily domain containing 2A	3.57	1.97	0.0237
SDR16C5	short chain dehydrogenase/reductase family 16C, member 5	3.50	2.23	0.0237
MOP-1	MOP-1	3.48	1.60	0.0237
OAS-2	2–5-oligoadenylate synthetase 2	3.43	1.74	0.0237
PHACTR1	phosphatase and actin regulator 1	3.43	1.55	0.0237
PIGA	phosphatidylinositol glycan anchor biosynthesis class A	3.42	1.51	0.0237
IFIT3	interferon-induced protein with tetratricopeptide repeats 3	3.42	1.96	0.0237
C1orf162	chromosome 1 open reading frame 162	3.40	1.54	0.0237
ATP8A1	ATPase, aminophospholipid transporter (APLT), class I, type 8	3.40	1.52	0.0237
FMO5	flavin containing monooxygenase 5	2.44	2.44	0.0237
GBP4	guanylate binding protein 4	3.34	1.92	0.0237
ZNF385B	zinc finger protein 385B	3.32	2.36	0.0237
SLCO4C1	solute carrier organic anion transporter family, member 4C1	3.25	2.11	0.0237

d = standardized change in expression (relative difference); q value = false discovery ratio