Table 2.
Results of the RegiSCAR scoring system used to diagnose drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome in two children
| Items | Patient 1 | Score: patient 1 | Patient 2 | Score: patient 2 |
|---|---|---|---|---|
| Fever ≥ 38.5 °C | Yes | 0 | Yes | 0 |
| Enlarged lymph nodes | Yes | 1 | Yes | 1 |
| Eosinophils a | Yes | 2 | Yes | 2 |
| Atypical lymphocytes | No | 0 | No | 0 |
| Skin rash > 50% of body surface area | Yes | 1 | Yes | 1 |
| Skin rash suggesting DRESS | Yes | 1 | Yes | 1 |
| Skin biopsy suggesting DRESS | Yes | 1 | Not applicable | 0 |
| Liver involvement | Yes | 1 | Yes | 1 |
| Resolution ≥ 15 days | No | -1 | No | -1 |
| Evaluation other potential causes b | Negative | 1 | Negative | 1 |
| Total score | 7 | 6 |
a: eosinophils 0.7–1.49 × 103/mmc = 1; ≥1.5 × 103/mmc = 2
b: include ANA, blood culture, serology for HVA/ HVB/ HVC, Chlamydia/ Mycoplasma pneumonia, other serology/PCR. None positive and ≥ 3 of the above negative = 1
Legend: Final score < 2: no case, final score 2–3: possible case, final score 4–5: probable case, and final score > 5: definite case