Table 1.

Frequencies (%) of regular use* of non-steroidal anti-inflammatory drugs (NSAID), other related and common medications in Women’s Health Initiative (WHI) dietary modification cohort (DM) by time

	Baseline (N=48834)					Year 1 (N=45036)					Year 3 (N=43323)					Year 6 (N=41610)					Year 9 (N=9865)
	DM		Comparison			DM		Comparison			DM		Comparison			DM		Comparison			DM		Comparison
Drug classes/types	N	%	N	%	p-value	N	%	N	%	p-value	N	%	N	%	p-value	N	%	N	%	p-value	N	%	N	%	p-value
Any NSAID	7024	35.95	10816	36.92	0.03	7024	35.95	10816	36.92	0.03	6227	36.20	9804	37.53	0.005	7566	46.01	11858	47.12	0.03	1999	51.34	3204	53.66	0.02
Aspirin	3922	20.07	6128	20.92	0.02	3922	20.07	6128	20.92	0.02	3923	22.80	6196	23.72	0.03	5239	31.86	8237	32.73	0.06	1469	37.72	2390	40.03	0.02
<325 mg	967	4.95	1532	5.23	0.07	967	4.95	1532	5.23	0.07	1587	9.23	2471	9.46	0.07	3144	19.12	4879	19.39	0.12	999	25.65	1650	27.63	0.06
⩾325 mg	2955	15.12	4596	15.69	0.07	2955	15.12	4596	15.69	0.07	2336	13.58	3725	14.26	0.07	2095	12.74	3358	13.34	0.12	470	12.07	740	12.39	0.06
Ibuprofen	2117	10.83	3264	11.14	0.29	2117	10.83	3264	11.14	0.29	1293	7.52	1995	7.64	0.64	1143	6.95	1733	6.89	0.80	267	6.86	402	6.73	0.81
Other NSAIDs	1920	9.83	2927	9.99	0.55	1920	9.83	2927	9.99	0.55	1771	10.29	2872	11.00	0.02	2431	14.78	3822	15.19	0.26	607	15.59	975	16.33	0.33
Other AID and analgesics
Corticosteroids	44	0.23	44	0.15	0.06	44	0.23	44	0.15	0.06	130	0.76	173	0.66	0.25	175	1.06	235	0.93	0.19	56	1.44	66	1.11	0.14
Acetaminophen	2168	11.10	3231	11.03	0.82	2168	11.10	3231	11.03	0.82	1518	8.82	2313	8.86	0.91	1685	10.25	2571	10.22	0.92	454	11.66	730	12.23	0.40
Other common medications
Antihyperlipidemics	1405	7.19	2170	7.41	0.37	1405	7.19	2170	7.41	0.37	2330	13.54	3732	14.29	0.03	3657	22.24	5836	23.19	0.02	1073	27.56	1674	28.04	0.60
Statins	1207	6.18	1836	6.27	0.69	1207	6.18	1836	6.27	0.69	2178	12.66	3507	13.43	0.02	3387	20.60	5460	21.70	0.007	984	25.27	1531	25.64	0.68
Bile sequestrants	81	0.41	123	0.42	0.93	81	0.41	123	0.42	0.93	46	0.27	55	0.21	0.23	59	0.36	100	0.40	0.53	13	0.33	31	0.52	0.18
Fibrate	148	0.76	247	0.84	0.30	148	0.76	247	0.84	0.30	122	0.71	190	0.73	0.83	231	1.40	298	1.18	0.05	80	2.05	106	1.78	0.32
Non-statins	230	1.18	368	1.26	0.44	230	1.18	368	1.26	0.44	185	1.08	269	1.03	0.65	369	2.24	527	2.09	0.30	145	3.72	219	3.67	0.89
Antidiabetics	725	3.71	1139	3.89	0.31	725	3.71	1139	3.89	0.31	869	5.05	1463	5.60	0.01	1190	7.24	1857	7.38	0.58	294	7.55	461	7.72	0.76
Antihypertensives	2136	10.93	3417	11.66	0.01	2136	10.93	3417	11.66	0.01	2659	15.46	4385	16.79	<0.001	3917	23.82	6316	25.10	0.003	1061	27.25	1707	28.59	0.15