Table 3.
Annualized incidence (%), and hazard rations and 95% confidence interval (CL) of colorectal cancer for dietary modification (DM) according to baseline NSAID use
| NSAIDs use | DM (14.2 ± 4.8 yrs*) | Comparison (14.4s ± 4.7yrs*) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | case |
Annualized % |
N | case |
Annualized % |
Hazard Ratio |
lower CL | upper CL |
P-value
for interaction |
||
| Any type | No | 12516 | 264 | 0.15% | 18478 | 337 | 0.13% | 1.14 | (0.96, | 1.34) | 0.14 |
| Yes | 7024 | 114 | 0.12% | 10816 | 191 | 0.12% | 0.92 | (0.73, | 1.16) | . | |
| Aspirin | No | 15618 | 318 | 0.14% | 23166 | 412 | 0.12% | 1.12 | (0.97, | 1.30) | 0.07 |
| Yes | 3922 | 60 | 0.11% | 6128 | 116 | 0.13% | 0.81 | (0.60, | 1.11) | . | |
| <325 mg | 967 | 13 | 0.10% | 1532 | 23 | 0.11% | 0.89 | (0.45, | 1.76) | 0.18 | |
| >= 325 mg | 2955 | 47 | 0.11% | 4596 | 93 | 0.14% | 0.80 | (0.56, | 1.13) | . | |
| Ibuprofen | No | 17423 | 336 | 0.14% | 26030 | 471 | 0.13% | 1.05 | (0.91, | 1.21) | 0.72 |
| Yes | 2117 | 42 | 0.14% | 3264 | 57 | 0.12% | 1.14 | (0.76, | 1.69) | . | |
| Other Nsaids | No | 17620 | 354 | 0.14% | 26367 | 490 | 0.13% | 1.07 | (0.93, | 1.23) | 0.66 |
| Yes | 1920 | 24 | 0.09% | 2927 | 38 | 0.09% | 0.95 | (0.57, | 1.58) | . | |
Stratified by age group, HT arm, baseline colorectal cancer, adjusted for time dependent CAD participation
*
Mean follow up time and its standard deviation