Table 2.

The incidence rate of adverse effect.

Type	The number of adverse effect		References
	Experimental group	Control group
Cutaneous pruritus	9	0	Huang et al., 2013; Xue et al., 2015; Yang M. et al., 2015
Palpitation	6	3	Yang M. et al., 2015; Li et al., 2016; Ye et al., 2017
Light-headed	7	1	Zhao et al., 2010; Huang et al., 2013; Wu, 2015
Headache	2	3	Ye et al., 2017
Dizziness	0	1	Yang M. et al., 2015
Hypokalemia	1	0	Ye et al., 2017
Abnormal liver function	3	2	Ye et al., 2017
Major adverse cardiac event	3	9	Wang, 2017
Leukocytosis	0	1	Xue et al., 2015
Vomiting	0	1	Ye et al., 2017
Total event	31/661	21/613	–
Incidence rate	4.7%	3.4%	–