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. 2018 Jul 25;9:545. doi: 10.3389/fneur.2018.00545

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Copyright © 2018 Raji, Ostwaldt, Opfer, Suppa, Spies and Winkler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Z-scores of calculated brain volumes. Brain volumes were normalized to the respective scanner-specific control cohort. Z-Scores for all regions were significantly different from zero (p < 0.0001 for all brain regions). Mean z-scores for the thalamus were significantly lower than all other brain volumes (p = 0.0295 for comparison with corpus callosum, p < 0.001 for all other comparisons, ANOVA with Bonferroni correction) in both the relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) patients. GM, gray matter; WM, white matter; BP, brain parenchyma.